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Welcome to the Molecular Health Sciences (MHS) Platform of ETH Zurich

30.09.2016

Inaugural Lecture: PD Dr. Ulrich auf dem Keller

The inaugural lecture of PD Dr. Ulrich auf dem Keller with the titel "Protease signaling networks in inflammation and repair " will take place on Friday, October 21, 2016, at 17.15 in HPL D32/34.  Read more 

26.09.2016

New Publication: The RNA-binding protein Vigilin is increased in hepatic steatosis and regulates VLDL secretion through modulation of Apob mRNA translation.

Vigilin is the largest RNA-binding protein of the KH domain family. The authors show that in the liver vigilin binds to CU-rich regions in the mRNA coding sequence of a subset of secretory proteins, including Apob  and other proatherogenic proteins, and regulates VLDL secretion and hepatic metabolism.   Read more 

19.09.2016

Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

PI3Kγ plays a key role in inflammatory diseases and cancer. Transgenic animals have been essential to study molecular mechanisms. We identify multiple additional genome mutations in a PI3Kγ-deficient mouse colony including a deleterious STOP mutation in the GM-CSFRa chain. The animals consequently lacked alveolar macrophages and succumbed rapidly to influenza virus infection. By separating the mutations, we established a unique Csf2ra mouse model to study intrinsic GM-CSFR signaling in vivo . Read more 

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01.10.2016
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