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Welcome to the Molecular Health Sciences (MHS) Platform of ETH Zurich


Non-coding solutions to developmental challenges

The seminar by Prof. Dr. Dónal O’Carroll (MRC Centre for Regenerative Medicine University of Edinburgh) takes place on Thursday, November 19 at 2pm in HPL D32 and is hosted by Prof. Constance Ciaudo. Guests are very welcome! Read more 


Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions.

MMP10 is highly expressed in keratinocytes at the wound edge and at the invasive front of tumors, but its function in tissue repair and carcinogenesis is unclear. In this paper researchers from the auf dem Keller group further characterized MMP10-dependent proteolysis and identified new substrates that are involved in cell adhesion, migration, proliferation and/or differentiation, indicating a contribution of MMP10 to local modulation of these processes during wound healing and cancer development. Read more 


The Lin28/let-7 axis is critical for myelination in the peripheral nervous system

MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. In this paper researchers from the Suter group present data suggesting that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases. Read more 

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