Publications

Publications concerning Cardiomyocytes

C. Weikert, M. Eppenberger-Eberhardt, H.M. Eppenberger (2003) Cellular engineering of ventricular adult rat cardiomyocytes. Cardiovasc Res 59 : 874 – 882.

D.A.Dätwyler, J.P.Magyar, C. Weikert, L.Wightman, E.Wagner, H.M.Eppenberger
(2003) Reactivation of the mitosis-promoting factor (MPF) in postmitotic cardiomyocytes. Cells Tissues Organs 175 : 61 – 71.

H.Meents , B.Enenkel , H.M.Eppenberger , R.G.Werner, M.Fussenegger (2002) Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-xL on productivity, cell survival and mitochondria number in CHO-DG44 grown in suspension and serum-free media. Biotechnol Bioeng. 80 : 706-716.

D.B. Sawyer, C.Zuppinger,T.A.Miller, H.M.Eppenberger, T.M.Suter (2002) Modulation of Anthracycline-Induced Myofibrillar Disarray in Rat Ventricular Myocytes by Neuregulin-1b and Anti-erbB2. Potential Mechanism for Trastuzumab-Induced Cardiotoxicity. Circulation 105, 1551-1554

L.O.Polontchouk, V.Valiunas, J.A. Haefliger, H.M.Eppenberger, R.Weingart (2002) Expression and regulation of connexin s in cultured ventricular myocytes isolated from adult rat hearts. Pflügers Arch- Eur J Physiol 443, 676-689.

D.Dyntar, M. Eppenberger-Eberhardt, K. Maedler, M.Pruschy, H.M.Eppenberger, G.A Spinas, M.Y. Donath (2001) Glucose and palmitic acid induce degeneration of myofibrils and modulate apopotosis in rat adult cardiomyocytes. Diabetes 50: 2105-2113.

E. Ehler, R.Horowitz, C. Zuppinger, R.L.Price, E. Perriard, M. Leu, P.Caroni, M. Sussman, H.M.Eppenberger, JC. Perriard (2001) Alterations at the intercalated disc associated with the absence of muscle LIM protein. J Cell Biol 153: 763-772.

J.P. Magyar, M.Nemir, E. Ehler, N. Suter, JC. Perriard, H.M.Eppenberger (2001) Mass production of embryoid bodies in microbeads. Ann NY Acad Sci. 944: 135-143.

D.A.Dätwyler, J.F.Magyar, V.Busceti, A.Hirschy, J.C.Perriard, J.E.Bailey, H.M.Eppenberger (2001) Recombinant Sindbis virus Allows expression and precise targeting of proteins of the contractile apparatus in cultured cardiomyocytes. Basic Res Cardiol 96, 630-635.

L. Polontchouk, J.Elbel, L. Eckert, J.Blum, E.Wintermantel, H.M.Eppenberger (2000) Titanium dioxide ceramics control the differentiated phenotype of cardiac muscle cells in culture, Biomaterials 21, 539-550.

Ch. Zuppinger, M.C. Schaub, H.M. Eppenberger (2000) Dynamicsof early contact formation in cultured adult rat cardiomyocytes studied by N-cadherin fused to green fluorescent protein, J. Mol. Cell. Cardiology 32, 539-555.

D.A. Dätwyler, H.M. Eppenberger, H.M. Koller, J.E. Bailey and J.P. Magyar(2000) Efficient gene delivery into cultured adult cardiomyocytes by recombinant SINDBIS virus. J.Molecular Medicine 77, 859-864.

M.Klainguti, S.Aigner, J.Kilo, H.M.Eppenberger, A.Mandinova, U.Aebi, M.C. Schaub, S.G.Shaw, T.Lüscher, D.Atar (2000) Lack of nuclear apoptosis in cardiomyocytes and increased endothelin-1 levels in a rat heart model of myocardial stunning, BasicResCardiol 32, 539-555.

C.Zuppinger, M.Eppenberger-Eberhardt, H.M.Eppenberger (2000) N-cadherin: Structure, function and importance in the formation of new intercalated disc-like cell contacts in cardiomyocytes, Heart Failure Reviews 5, 251-257.

U.Kaufmann, C.Zuppinger,Z. Waibler. M.Rudiger, C. Urbich, B. M. Jockusch, H.M.Eppenberger, A, Starzinski-Powitz (2000) The armadillo repeat region targets ARVCF to cadherin-based cellular junctions, J of Cell Science 113, 4121-4135.

H.M.Eppenberger and J.C. Perriard (1999) Das lange Leben der Herzmuskelzellen. ETH-Bulletin 273, 34-37 .

H.M. Eppenberger and Ch. Zuppinger/1999) In vitro reestablishment of cell-cell contacts in adult rat cardiomyocytes. Functional role of transmembrane components in the function of new intercalated disc-like cell contacts. FASEB J. 13, 88-90.

X. Mazur, H.M.Eppenberger, J.E. Bailey and M. Fussenegger(1999) A novel autoregulated proliferation controlled production process using recombinant CHO cells. Biotechnology and Bioengineering, 65, 144-150.

J.M. Magyar and H.M. Eppenberger (1999) Factors involved in the cell cycle arrest of adult rat cardiomyocytes. Cell Engineering, Kluver Acad. Publications, 239-254.

G. Fillipini, S. Griffin, M. Uhr, H.M. Eppenberger, J. Bonilla, F. Cavalli, G. Soldati (1998)A novel flow cytometric method for the quantification of p53 gene expression. Cytometry 31:180-186.

B.A. Harder, M.A. Hefti, H.M. Eppenberger, M.C. Schaub (1998) Differential protein localization in sarcomeric and nonsarcomeric contractile structures of cultured cardiomyocytes. J. Struct. Biol. 122: 162-175.

M.C. Schaub, M.A. Hefti, B.A. Harder, H.M. Eppenberger (1998 ) Triiodothyronine restricts myofibrillar growth and enhances beating frequency in cultured adult rat cardiomyocytes. Basic Res Cardiol 93 (5): 391-395.

J.H.M. van Adrichem, K.O. Börnsen, H. Conzelmann, M.A.S. Gass, H.M. Eppenberger, G.M. Kresbach, M. Ehrat, C.H. Leist (1998) Investigation of protein patterns in mammalian cells and culture supernatants by matrix-assisted laser desorption/ionization mass spectrometry. Anal.Chem. 70, 923-930.

Eppenberger-Eberhardt, M., Aigner, S., Donath, M.Y., Kurer, V., Walther, P., Zuppinger, C., Schaub, M.C., Eppenberger, H.M. (1997) IGF-I and bFGF differentially influence atrial natriuretic factor and a-smooth muscle actin expression in cultured atrial compared to ventricular adult rat cardiomyocytes. J. Mol. Cell Cardiol. 29, 2027-2039.

Schaub, M.C., Hefti, M.A., Harder, B.A., Eppenberger, H.M. (1997). Various hypotrophic stimuli induce distinct phenotypes in cardiomyocytes. J. Mol. Med. 75, 901-920.

Hefti, M.A., Harder, B.A., Eppenberger, H.M., Schaub, M.C. (1997). Signaling pathways in cardiac myocyte hypertrophy. J. Mol. Cell Cardiol. 29, 2873-2812.

Gosteli-Peter, M.A., Harder, B. A., Eppenberger, H.M., Zapf, J., Schaub, M.C. (1996) Triiodothyronine induces overexpression of a-smooth muscle actin, restricts myofibrillar expansion and is permissive for the action of basic fibroblast growth factor and insulin-like growth factor I in adult rat cardiomyocytes. J. Clin. Invest. 8, 1737-1744.

Harder, B.A., Schaub, M.C., Eppenberger, H.M., Eppenberger-Eberhardt, M. (1996) Influence of fibroblast growth factor (bFGF) and insulin-like growth factor (IGF-I) on cytoskeletal and contractile structures and on atrial natriuretic factor (ANF) expression in adult rat ventricular cardiomyocytes in culture. J. Mol. Cell Cardiol. 28, 19-31.

Hertig, C.M., Eppenberger-Eberhardt, M., Koch, S., Eppenberger, H.M. (1996) Ncadherin in adult rat cardiomyocytes in culture. I. Functional role of N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant. Journal of Cell Science 109,1-10.

Hertig, C.M., Butz, S., Koch, S., Eppenberger-Eberhardt, M., Kemler, R., Eppenberger, H.M. (1996) N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Journal of Cell Science 109, 11-20.

Renner, W.A., Lee, K.H., Hatzimanikatis, V., Bailey, J.E., Eppenberger, H.M. (1995) Recombinant cyclin E expression activates proliferation and obviates surface attachment of chinese hamster ovary (CHO) cells in protein-free medium. Biotechnology and Bioengineering 47, 476-482.

Eppenberger, H.M., Hertig, C., Eppenberger-Eberhardt, M. (1994) Adult rat cardiomyocytes in culture: A model system to study the plasticity of the differentiated cardiac penotype at the molecular and cellular level. Trends in Cardiovascular Medicine (TCM) 4, 187-193.

Donath, M., Zapf, J., Froesch, R., Eppenberger-Eberhardt, M., Eppenberger, H.M. (1994) IGF-1 stimulates myofibril development and decreases a-smooth muscle actin of adult cardiomyocytes. PNAS 91, 1686-1690.

Messerli, M., Eppenberger-Eberhardt, M., Rutishauser, B., Schwarb, P., von Arx, P., Koch-Schneidemann, S., Eppenberger, H.M., Perriard, J.-C. (1993) Remodelling of cardiomyocyte cytoarchitecture visualized by three-dimensional (3D) confocal microscopy. Histochemistry 100, 193-202.

Eppenberger-Eberhardt, M., Messerli, M., Eppenberger, H.M., Reinecke, M. (1993) New occurrence of atrial natriuretic factor and storage in secretorially active granules in adult rat ventricular cardiomyocytes in long-term culture. J. Mol. Cell Cardiol. 25, 753-757.

Eppenberger-Eberhardt, M., Riesinger, I., Messerli, M., Schwarb, P., Müller, M., Eppenberger, H.M., Wallimann, T. (1991) Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase. J. Cell Biol. 113, 289-302.

Eppenberger, M., Flamme, I., Kurer, V., Eppenberger, H.M. (1990) Reexpression of a-smooth muscle actin isoform in cultured adult rat cardiomyocytes. Dev. Biol. 139, 269-278.

Eppenberger, M., Hauser, I., Baechi, T., Schaub, M.C., Brunner, U.T., Dechesne, C.A., Eppenberger, H.M. (1988) Immuno-cytochemical analysis of the regeneration of myofibrils in long-term cultures of adult cardiomyocytes of the rat. Devel.Biol. 130, 1-15.