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One important and ubiquitous mechanism for signal transduction is the reversible phosphorylation of proteins that participate in a particular signaling pathway. The phosphorylation and dephosphorylation of proteins is achieved by protein kinases and phosphatases, respectively. Among the roughly 500 protein kinases encoded by the human genome, we investigate a few important protein kinases participating in relevant pathways with known involvement in the control of inflammation and metabolism, namely AMPK, LKB1 and TAK1. Current research is directed towards identifying new treatment options in major disease areas, such as diabetes and cardiovascular disease.

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Sun Apr 30 12:45:52 CEST 2017
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