Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions.

MMP10 is highly expressed in keratinocytes at the wound edge and at the invasive front of tumors, but its function in tissue repair and carcinogenesis is unclear. In this paper researchers from the auf dem Keller group further characterized MMP10-dependent proteolysis and identified new substrates that are involved in cell adhesion, migration, proliferation and/or differentiation, indicating a contribution of MMP10 to local modulation of these processes during wound healing and cancer development.