The Lin28/let-7 axis is critical for myelination in the peripheral nervous system

MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. In this paper researchers from the Suter group present data suggesting that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases.

by Andrea Martina Kyburz Kooznetsoff
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