Publication: Dicer, a new regulator of pluripotency exit and LINE-1 elements in mouse embryonic stem cells.
Bodak et al. report that murine Dicer is required for exit from pluripotency state of mouse embryonic stem cells (mESCs). Moreover, in Dicer_knockout mESCs the pluripotency network is reinforced and there is a strong accumulation of LINE-1 mRNA and proteins, leading to an increased retrotransposition rate. Indeed, DICER is essential for stemness and genome integrity.
by
Ruth Henneberger