Publication: The role of RNA interference in stem cell biology: beyond the mutant phenotypes

Most of the RNAi proteins are essential for the differentiation into the three germ layers of mESCs. This study of Bodak et al reviews the current understanding of how RNAi proteins regulate stem cell identity with the new advances in the stem cell field and the recent non-canonical functions. Finally, they propose the re-evaluation of RNAi mutant phenotypes as non-canonical (miRNA independent) functions may contribute to the molecular mechanisms governing mESCs commitment. 

by Ruth Henneberger
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