Prof. Dr. Sabine Werner
Tissue Repair & Cancer
Tissue injury initiates a series of events, which lead to at least partial reconstruction of the affected body site. Many conditions are associated with impaired tissue repair, including old age, steroid treatment and chronic diseases such as diabetes and cancer. A prerequisite for the improvement of impaired healing is a thorough understanding of the underlying cellular and molecular mechanisms. Our laboratory studies these mechanisms, focusing on the roles of growth factors and reactive oxygen species in the repair process. One of the most exciting aspects of our work is the analysis of the parallels between tissue repair and cancer. We use state-of-the art approaches, including functional genomics and proteomics, 2D and 3D primary cell culture systems, and genetically modified mice for our research. Through collaboration with clinical partners we determine the importance of our findings for the human situation (see also SKINTEGRITY - a flagship project of "Hochschulmedizin Zurich", which is chaired by Sabine Werner - http://www.hochschulmedizin.uzh.ch/de/projekte/skintegrity.html).