2024
Publication by Kristin Seltmann et al.: Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocytes survival and migration.
Seltmann et al. discovered that the transmembrane protein CLCA2 is transported to the nucleus of keratinocytes via extracellular vesicles (EVs). Nuclear CLCA2 promotes expression of Wnt target genes and is required for the suppression of keratinocyte migration and for survival of these cells under hyperosmotic stress conditions.
Publication by Paul Hiebert et al.: A lysyl oxidase-responsive collagen peptide illuminates collagen remodeling in wound healing.
Hiebert et al. used a collagen peptide sensor to visualize lysyl oxidase-dependent collagen formation and remodeling during wound healing. The probe selectively detects newly produced or remodeling collagen, but not matured collagen fibers, and can be applied for in vivo wound imaging and for discerning differential remodeling in mice with altered collagen dynamics.
Seminar Announcement: "Cerebral organoids: Modelling human brain development and neurological disorders in 3D cell culture" by Jürgen Knoblich, Director IMBA, Vienna.
The orgaizing committee of the IMHS Seminar Series "The New Generation Scientists Invite" is pleased to invite you to the first Seminar held by Dr. Jürgen Knoblich, who pioneered organoid research and is the current director of the IMBA in Vienna. The Seminar will take place on Tuesday, 27.02.2024, at 10:30, in the seminar room HPM H33.
Publication by Lena Cords et al.: Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer.
Cords and colleagues report a spatial resolved single-cell imaging mass cytometry analysis of cancer-associated fibroblasts (CAFs) in a non-small cell lung cancer (NSCLC) cohort of 1’070 patients. Their data identify phenotypic and spatial features of CAFs that are associates with patient outcome in NSCLC.