2015
Genome defense by germline small RNAs
The seminar by Dr. Ramesh Pillai, Group Leader at EMBL Grenoble, European Molecular Biology Laboratory Grenoble, takes place on Thursday, December 3 at 2pm in HPL D32 and is hosted by Prof. Constance Ciaudo. Guests are very welcome!
ETH Medal for best PhD thesis for Remy Denzler
Non-coding solutions to developmental challenges
The seminar by Prof. Dr. Dónal O’Carroll (MRC Centre for Regenerative Medicine University of Edinburgh) takes place on Thursday, November 19 at 2pm in HPL D32 and is hosted by Prof. Constance Ciaudo. Guests are very welcome!
Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations
Pharmacologic activation of the transcription factor Nrf2 has been suggested to offer a strategy for cancer prevention. In this study, researchers from the Werner and Schäfer group present evidence that Nrf2 activation leads to metabolic alterations, which promotes the survival of keratinocytes during the tumor promotion phase. These results reveal an unexpected tumor-promoting activity of activated Nrf2 during early skin carcinogenesis.
Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions.
MMP10 is highly expressed in keratinocytes at the wound edge and at the invasive front of tumors, but its function in tissue repair and carcinogenesis is unclear. In this paper researchers from the auf dem Keller group further characterized MMP10-dependent proteolysis and identified new substrates that are involved in cell adhesion, migration, proliferation and/or differentiation, indicating a contribution of MMP10 to local modulation of these processes during wound healing and cancer development.