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NEXUS user meeting (Theragnostics Discovery Unit): Monday, May 8, 2017, 10:15 at HPL J34

The goal of this meeting is to discuss current and future methods, learn about needs and give the users opportunity to shape the NEXUS service catalogue. Blaise Calpe will speak about a 3D culture high-content screen to identify hypoxia induced vulnerabilities of cancer cells , and Falco Kilchmann will present the technical background on chemical tools offered at NEXUS. You will also have the chance to discuss implementation of your screening project and new methods/technologies required. Read more 


Publication: Vector Integration Sites Identification for Gene-Trap Screening in Mammalian Haploid Cells.

Forward genetic screens using retroviral gene-trap vectors in a haploid genome revolutionized the investigation of molecular networks in mammals. The analysis of human and mouse haploid screens allowed the authors Yu and Ciaudo to describe PhiT-seq data and to define quality control steps. Integration of transcriptomic data improved the performance of candidate gene identification. Finally, the authors developed: VISITs, a dedicated pipeline for analyzing PhiT-seq data. Read more 


Publication: Versatility of DGCR8 controls stem cell fate

This feature editorial by Cirera-Salinas et al. is a follow up on their recent paper in JCB (2017) entitled "Nanocanonical function of DGCR8 controls mESC exit from pluripotency".  Read more 


Seminar Announcement: Ribosome biogenesis and its surveillance pathway in stem cells functions and tissue homeostasis; March 09, 2017, 5 pm in HPL D32

The Molecuar Health Sciences Seminar Ribosome biogenesis and its surveillance pathway in stem cells functions and tissue homeostasis  by Dr. Michel Cohen-Tannoudji from the Unite de Génétique Fonctionelle de la Souris, Institut Pasteur, will take place on Thursday, May 9, 2017, at 5 pm in HPL D32 at ETH Hönggerberg. Guests are very welcome! Read more 


Publication: Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility

This study by Ahmed et al. reveals that miR-7a2 critically regulates sexual maturation and reproductive function by interconnecting miR-7 genomic circuits that regulate FSH and LH synthesis and secretion through their effects on pituitary prostaglandin and BMP4 signaling.  Read more 


Seminar Announcement: Cardiac specification during embryogenesis and human stem cell differentiation; March 02, 2017, 2 pm in HPL J34

The Molecuar Health Science Seminar Cardiac specification during embryogenesis and human stem cell differentiation  by Prof. Nicole Dubois, Icahn School of Medicine at Mount Sinai, New York, will take place on Thursday, March 02, 2017, at 5 pm in HPL J34 at ETH Hönggerberg. Guests are very welcome!  Read more 


Seminar Announcement: Cross-species genetic mapping of targets in mitochondria, metabolism and aging; February 13, 2017, 5 pm in HCI G3

The Molecular Health Sciences and EPIC Research Progress Seminar Cross-species genetic mapping of targets in mitochondria, metabolism and aging  by Prof. Johan Auwerx, head of the Laboratory of Integrative and Systems Physiology at EPFL in Lausanne, will take place on Monday, February 13, 2017, at 5 pm in HCI G3 at ETH Hönggerberg. Guest are very welcome!  Read more 


Publication: The role of RNA interference in stem cell biology: beyond the mutant phenotypes

Most of the RNAi proteins are essential for the differentiation into the three germ layers of mESCs. This study of Bodak et al reviews the current understanding of how RNAi proteins regulate stem cell identity with the new advances in the stem cell field and the recent non-canonical functions. Finally, they propose the re-evaluation of RNAi mutant phenotypes as non-canonical (miRNA independent) functions may contribute to the molecular mechanisms governing mESCs commitment.  Read more 


Publication: Non-canonical function of DGCR8 controls mESCs exit from pluripotency

DGCR8 is essential for mouse early development and microRNA biogenesis. Cirera-Salinas et al. report a new non-canonical function of DGCR8 essential for the exit from pluripotency of mouse embryonic stem cells. Read more 


Publication: A Bioinspired Ultraporous Nanofiber-Hydrogel Mimic of the Cartilage Extracellular Matrix

In this study by Formica et al. cryoelectrospinning is used to create a stable, ultraporous nanofiber network. The electrospun scaffold can be drug-loaded and embedded in a polyanionic alginate hydrogel. The fibrillar component significantly reinforces the chondroinductive but weak hydrogel, creating a mimic of the cartilage extracellular matrix which is stable in vivo. Read more 


Seminar Announcement: Dendritic Cell and Macrophage Biology: from Development to Functions; January 09, 4:30 pm in HPL D32

The Molecular Health Sciences Seminar "Dendritic Cell and Macrophage Biology: from Development to Functions " by Prof. Florent Ginhoux, Singapore Immunology Network (SIgN) and Agency for Science, Technology and Research (A*STAR), will take place on Monday, January 09, at 4:30 pm in HPL D32. Guest are very welcome! Read more 


Seminar Announcement: Cellular senescence as a result of diverse genotoxic stresses and its role in tissue homeostasis; January 12, 2 pm in HPL J34

The Molecular Health Sciences Seminar "Cellular senescence as a result of diverse genotoxic stresses and its role in tissue homeostasis " by Dr. Dimitris Kletsas, Research Director at the Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, Athens, Greece, will take place on Thursday, January 12, at 2 pm in HPL J34. Guest are very welcome! Read more 


Publication: Dicer, a new regulator of pluripotency exit and LINE-1 elements in mouse embryonic stem cells.

Bodak et al. report that murine Dicer  is required for exit from pluripotency state of mouse embryonic stem cells (mESCs). Moreover, in Dicer _knockout mESCs the pluripotency network is reinforced and there is a strong accumulation of LINE-1 mRNA and proteins, leading to an increased retrotransposition rate. Indeed, DICER is essential for stemness and genome integrity. Read more 


Publication: Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages

This study by Antsiferova et al. demonstrates that activin overexpression is an early event in murine and human skin tumorigenesis. We demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages, and we identify novel activin targets involved in tumor formation. Read more 


Publication: Foxa1 is essential for development and functional integrity of the subthalamic nucleus

The study by Gasser et al. identifies Foxa1 as an essential transcription factor for the development and functional maintenance of the subthalamic nucleus that has been implicated in the etiology of neurodegenerative diseases such as Huntington's and Parkinson's disease. Read more 


Seminar: Genome integrity and piRNAs; December 6, at 2 pm

The Molecular Health Sciences Seminar "Genome integrity and piRNAs" by Dr. Séverine Chambeyron from the Non-coding RNA, epigenetics and genome stability CNRS, Institut de Génétique Humaine, Montpellier, France, will take place on Tuesday, December 6, at 2 pm in HPL D 32. Guest are very welcome!    Read more 


Publication: Impact of miRNA Levels, Target-Site Complementarity and Cooperativity on ceRNA-Regulated Gene Expression.

Denzler et al. show that effects of competing miRNA sites are insensitive to reduced miRNA activity, that low-affinity/background miRNA sites contribute to competition, and that adjacent miRNA sites can cooperatively sequester miRNAs. Overall, their results reduce the prospects of observing an effect from a ceRNA.  Read more 


Introductory Lecture: PD Dr. Ulrich auf dem Keller

The introductory lecture of PD Dr. Ulrich auf dem Keller with the titel "Protease signaling networks in inflammation and repair " will take place on Friday, October 21, 2016, at 17.15 in HPL D32/34.  Read more 


Publication: The RNA-binding protein Vigilin is increased in hepatic steatosis and regulates VLDL secretion through modulation of Apob mRNA translation.

Vigilin is the largest RNA-binding protein of the KH domain family. The authors show that in the liver vigilin binds to CU-rich regions in the mRNA coding sequence of a subset of secretory proteins, including Apob  and other proatherogenic proteins, and regulates VLDL secretion and hepatic metabolism.   Read more 


Publication: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

PI3Kγ plays a key role in inflammatory diseases and cancer. Transgenic animals have been essential to study molecular mechanisms. We identify multiple additional genome mutations in a PI3Kγ-deficient mouse colony including a deleterious STOP mutation in the GM-CSFRa chain. The animals consequently lacked alveolar macrophages and succumbed rapidly to influenza virus infection. By separating the mutations, we established a unique Csf2ra mouse model to study intrinsic GM-CSFR signaling in vivo . Read more 

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Sun Apr 30 03:59:36 CEST 2017
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