Publication by Kristin Seltmann et al.: Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocytes survival and migration.

Seltmann et al. discovered that the transmembrane protein CLCA2 is transported to the nucleus of keratinocytes via extracellular vesicles (EVs). Nuclear CLCA2 promotes expression of Wnt target genes and is required for the suppression of keratinocyte migration and for survival of these cells under hyperosmotic stress conditions.