Publication: Impact of miRNA Levels, Target-Site Complementarity and Cooperativity on ceRNA-Regulated Gene Expression.

Denzler et al. show that effects of competing miRNA sites are insensitive to reduced miRNA activity, that low-affinity/background miRNA sites contribute to competition, and that adjacent miRNA sites can cooperatively sequester miRNAs. Overall, their results reduce the prospects of observing an effect from a ceRNA.