Publications from MHS

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Publication: Vector Integration Sites Identification for Gene-Trap Screening in Mammalian Haploid Cells.

Forward genetic screens using retroviral gene-trap vectors in a haploid genome revolutionized the investigation of molecular networks in mammals. The analysis of human and mouse haploid screens allowed the authors Yu and Ciaudo to describe PhiT-seq data and to define quality control steps. Integration of transcriptomic data improved the performance of candidate gene identification. Finally, the authors developed: VISITs, a dedicated pipeline for analyzing PhiT-seq data. Read more 


Publication: Versatility of DGCR8 controls stem cell fate

This feature editorial by Cirera-Salinas et al. is a follow up on their recent paper in JCB (2017) entitled "Nanocanonical function of DGCR8 controls mESC exit from pluripotency".  Read more 


Publication: Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility

This study by Ahmed et al. reveals that miR-7a2 critically regulates sexual maturation and reproductive function by interconnecting miR-7 genomic circuits that regulate FSH and LH synthesis and secretion through their effects on pituitary prostaglandin and BMP4 signaling.  Read more 


Publication: The role of RNA interference in stem cell biology: beyond the mutant phenotypes

Most of the RNAi proteins are essential for the differentiation into the three germ layers of mESCs. This study of Bodak et al reviews the current understanding of how RNAi proteins regulate stem cell identity with the new advances in the stem cell field and the recent non-canonical functions. Finally, they propose the re-evaluation of RNAi mutant phenotypes as non-canonical (miRNA independent) functions may contribute to the molecular mechanisms governing mESCs commitment.  Read more 


Publication: Non-canonical function of DGCR8 controls mESCs exit from pluripotency

DGCR8 is essential for mouse early development and microRNA biogenesis. Cirera-Salinas et al. report a new non-canonical function of DGCR8 essential for the exit from pluripotency of mouse embryonic stem cells. Read more 

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Mon Jun 26 20:00:12 CEST 2017
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